{"id":89515,"date":"2026-07-15T11:46:00","date_gmt":"2026-07-15T11:46:00","guid":{"rendered":"https:\/\/site.itshrt.com\/worldnews\/alzheimers-blood-test-may-predict-whos-likely-to-develop-symptoms-in-5-to10-years\/"},"modified":"2026-07-15T11:46:00","modified_gmt":"2026-07-15T11:46:00","slug":"alzheimers-blood-test-may-predict-whos-likely-to-develop-symptoms-in-5-to10-years","status":"publish","type":"post","link":"https:\/\/site.itshrt.com\/worldnews\/alzheimers-blood-test-may-predict-whos-likely-to-develop-symptoms-in-5-to10-years\/","title":{"rendered":"Alzheimer&#8217;s blood test may predict who&#8217;s likely to develop symptoms in 5 to10 years"},"content":{"rendered":"<p> <script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-6606220950177433\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<!-- ItShrt World News -->\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-client=\"ca-pub-6606220950177433\"\r\n     data-ad-slot=\"1882483372\"\r\n     data-ad-format=\"auto\"\r\n     data-full-width-responsive=\"true\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script>\r\n<br \/>\n<\/p>\n<div id=\"\">\n<p><em>Washington <\/em>\u2014 A blood test may predict if apparently healthy older adults are likely to develop <a href=\"https:\/\/www.cbsnews.com\/feature\/alzheimers-disease-and-dementia\/\" target=\"_blank\" data-invalid-url-rewritten-http=\"\">Alzheimer&#8217;s<\/a> symptoms in the next five or 10 years, researchers reported Wednesday.<\/p>\n<p>That information could be reassuring or terrifying, but for now it&#8217;s a potential tool to speed drug development by helping to identify and enroll high-risk people into studies of possible Alzheimer&#8217;s treatments or preventive strategies.  <\/p>\n<p>Already large clinical trials are testing if certain drugs could prevent or at least delay the disease &#8211; and if any of those pan out, doctors will need an easy way to tell who should try them. <\/p>\n<p>The scientists behind the new study stress that it&#8217;s too soon for healthy people to seek out the so-called p-tau217 test, which is currently used to help diagnose whether people experiencing cognitive problems have Alzheimer&#8217;s or another disorder. <\/p>\n<p>&#8220;Wait and get tested when you can potentially do something about it,&#8221; stressed Dr. Reisa Sperling of the Mass General Brigham Neuroscience Institute, the study&#8217;s senior author. &#8220;At this point, it wouldn&#8217;t change what I would tell someone to do. I&#8217;d still tell them to eat well, sleep well, exercise a lot and stay engaged.&#8221; <\/p>\n<p>The new findings showed that symptom-free older adults who harbored very high levels of p-tau217 had a 38% risk of developing cognitive impairment over five years. That risk grew to 78% by 10 years. <\/p>\n<p>The research was published in JAMA and presented at the Alzheimer&#8217;s Association International Conference in London. <\/p>\n<p>It&#8217;s not clear exactly what causes Alzheimer&#8217;s, but its telltale markers are brain-clogging amyloid plaques and neuron-killing tau tangles. The p-tau217 test measures a form of tau that correlates with how much plaque buildup someone has and gives a hint about tangles, Sperling said.<\/p>\n<h2>Details on the study \u00a0<\/h2>\n<p>The Mass General Brigham team analyzed data from 2,684 older adults who were healthy when they&#8217;d joined some long-running Alzheimer&#8217;s studies, receiving the p-tau217 blood test at enrollment and yearly cognitive checkups. Between the earliest enrollment in 2004 and last year, about 478 had developed cognitive impairment. <\/p>\n<p>Study participants with very low p-tau217 levels likewise had a low risk of developing cognitive impairment over the five- to 10-year period. <\/p>\n<p>There&#8217;s a conundrum in predicting Alzheimer&#8217;s: Lots of people harbor high levels of amyloid plaques yet never get dementia. A leading theory is that at some point amyloid buildup triggers an abnormal type of tau to form tangles, leading to symptoms. <\/p>\n<p>Sperling said the blood test data offers some new clues. While different intermediate levels of p-tau217 signaled progressive risk, only the very highest level seemed to correlate with other evidence about that tipping point. <\/p>\n<p>&#8220;This is a gradual process where amyloid and tau build up in the brain and this blood-based biomarker is telling you how far you are in that process,&#8221; she said.<\/p>\n<h2>Some researchers say &#8220;not so fast&#8221;<\/h2>\n<p>Scientists not involved in the study praised it but also offered some reasons to be cautious. One is that only a small fraction of study participants had been tracked for a full decade, so there&#8217;s less confidence in the 10-year risk estimate than the five-year risk estimate.  <\/p>\n<p>Also, the predictions could be clouded by other factors &#8211; older people may be at risk of dying from something else, or have heart-related problems that can cause vascular dementia rather than Alzheimer&#8217;s, noted Drs. Suzanne Schindler of Washington University in St. Louis and David Wolk of the University of Pennsylvania in a commentary published in JAMA. <\/p>\n<p>The blood tests &#8220;are not yet precise enough to guide individualized prognosis,&#8221; wrote Schindler, who also studies p-tau217&#8217;s prognostic potential, and Wolk. Still, they said the new work has &#8220;provided a crucial piece of the puzzle.&#8221; <\/p>\n<p>Already &#8220;we have people coming saying, &#8216;I want this blood test. I have a family history of Alzheimer&#8217;s disease,'&#8221; said Jessica Langbaum of the Banner Alzheimer&#8217;s Institute in Phoenix, something she strongly discourages &#8211; for now. <\/p>\n<p>&#8220;These findings are quite strong,&#8221; Langbaum added, and a predictive blood test would be &#8220;really important&#8221; &#8211; but only if ongoing studies eventually find a drug that could help people before symptoms begin.<\/p>\n<section class=\"content__body--footer\">\n<\/section>\n<p>  <!-- data-recirc-source=\"chartbeat\" --><\/p>\n<aside class=\"component list recirculation component--type-recirculation  component--type-recirculation-collection\">\n<div class=\"component__heading-wrapper recirc\">\n<h3 class=\"component__title\">Alzheimer&#8217;s Disease and Dementia<br \/>\n                          <a href=\"https:\/\/www.cbsnews.com\/feature\/alzheimers-disease-and-dementia\/?intcid=CNI-00-10aaa3a\" class=\"component__view-more component__view-more--lg\" 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window.adsbygoogle || []).push({});\r\n<\/script>\r\n<br \/>\n<br \/><a href=\"https:\/\/www.cbsnews.com\/news\/alzheimers-blood-test-5-to-10-years\/\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Washington \u2014 A blood test may predict if apparently healthy older adults are likely to develop Alzheimer&#8217;s symptoms in the<\/p>\n","protected":false},"author":1,"featured_media":89516,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[36],"tags":[8828],"class_list":["post-89515","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health-2","tag-alzheimer039s-disease"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Alzheimer&#039;s blood test may predict who&#039;s likely to develop symptoms in 5 to10 years - World News<\/title>\n<meta name=\"description\" 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