{"id":86179,"date":"2026-06-25T20:36:19","date_gmt":"2026-06-25T20:36:19","guid":{"rendered":"https:\/\/site.itshrt.com\/worldnews\/medical-journal-retracts-study-claiming-cancer-therapy-is-more-effective-when-given-in-the-morning\/"},"modified":"2026-06-25T20:36:19","modified_gmt":"2026-06-25T20:36:19","slug":"medical-journal-retracts-study-claiming-cancer-therapy-is-more-effective-when-given-in-the-morning","status":"publish","type":"post","link":"https:\/\/site.itshrt.com\/worldnews\/medical-journal-retracts-study-claiming-cancer-therapy-is-more-effective-when-given-in-the-morning\/","title":{"rendered":"Medical Journal Retracts Study Claiming Cancer Therapy Is More Effective When Given in the Morning"},"content":{"rendered":"<p> <script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-6606220950177433\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<!-- ItShrt World News -->\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-client=\"ca-pub-6606220950177433\"\r\n     data-ad-slot=\"1882483372\"\r\n     data-ad-format=\"auto\"\r\n     data-full-width-responsive=\"true\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script>\r\n<br \/>\n<\/p>\n<div data-testid=\"companionColumn-0\">\n<div class=\"css-53u6y8\">\n<p class=\"css-140ip4z e1me5xab0\">Early this year, a medical journal article caught the attention of cancer patients and doctors worldwide because of its extraordinary conclusion. Simply changing the time of day that immunotherapy was administered appeared to produce a stunning benefit for lung cancer patients.<\/p>\n<p class=\"css-140ip4z e1me5xab0\">Those who received IV infusions in the morning had their cancer kept at bay for twice as long as those who got it in the afternoon, according to the results from a clinical trial in China and <a class=\"css-yywogo\" href=\"https:\/\/www.nature.com\/articles\/s41591-025-04181-w\" title=\"\" rel=\"noopener noreferrer\" target=\"_blank\">published in the journal Nature Medicine<\/a> in February. The study also reported that the patients lived nearly twice as long.<\/p>\n<p class=\"css-140ip4z e1me5xab0\">Several oncologists said that in recent months they and their hospitals had received a flurry of calls from patients inquiring about switching to morning infusions.<\/p>\n<p class=\"css-140ip4z e1me5xab0\">But on Wednesday, Nature Medicine retracted the study, citing a list of inconsistencies and irregularities in the trial\u2019s design and results.<\/p>\n<\/div>\n<aside class=\"css-ew4tgv\" aria-label=\"companion column\"\/><\/div>\n<div data-testid=\"companionColumn-1\">\n<div class=\"css-53u6y8\">\n<p class=\"css-140ip4z e1me5xab0\">\u201cIt was too good to be true,\u201d said Dr. Toni Choueiri, an oncologist at the Dana-Farber Cancer Institute in Boston, who helped conduct the post-publication review that led to the retraction.<\/p>\n<p class=\"css-140ip4z e1me5xab0\">Among the issues that the journal cited <a class=\"css-yywogo\" href=\"https:\/\/www.nature.com\/articles\/s41591-026-04508-1\" title=\"\" rel=\"noopener noreferrer\" target=\"_blank\">in its retraction notice<\/a>: Records that were supposed to be locked before the study started were changed midway through. There were discrepancies between the Chinese version of the study\u2019s plan and the translated version. Every patient remained treated and tracked in the study\u2019s first year, and no one dropped out because of side effects \u2014 highly unusual in an oncology study. And unusual patterns were found in the timing of follow-up scans.<\/p>\n<p class=\"css-140ip4z e1me5xab0\">\u201cDue to the amount and nature of the problems identified, the editors no longer have confidence in the integrity of the results,\u201d the journal said.<\/p>\n<p class=\"css-140ip4z e1me5xab0\">Most of the study\u2019s 28 authors were in China, with several collaborators in Europe. The study was funded by the Chinese government.<\/p>\n<p class=\"css-140ip4z e1me5xab0\">China has been pumping money into its hospitals and drug companies, fueling a surge of patents, publications and new clinical trials. In just a few years, the country has rapidly transformed into a <a class=\"css-yywogo\" href=\"https:\/\/www.nytimes.com\/2026\/05\/30\/business\/china-lung-cancer-drugs-asco.html\" title=\"\">powerhouse in drug development<\/a>, a shift that some U.S. officials, doctors and executives see as a threat to longstanding American dominance in the field.<\/p>\n<\/div>\n<aside class=\"css-ew4tgv\" aria-label=\"companion column\"\/><\/div>\n<div data-testid=\"companionColumn-2\">\n<div class=\"css-53u6y8\">\n<p class=\"css-140ip4z e1me5xab0\">China\u2019s critics often question the reliability of its biomedical research. Experts said that, similar to studies in the United States, China\u2019s research output spans a wide range in quality: Some Chinese scientists run their studies at the most meticulous standards. Others were said to cut corners.<\/p>\n<p class=\"css-140ip4z e1me5xab0\">Dr. Yongchang Zhang, the study\u2019s senior author, said in a statement that an internal review had \u201cconfirmed that part of the study execution and manuscript preparation might not reach the standards for publication in a high-impact journal.\u201d<\/p>\n<p class=\"css-140ip4z e1me5xab0\">Dr. Zhang, a researcher at the Chinese hospital where the study was conducted, added: \u201cWe acknowledge these shortcomings and sincerely apologize for any inconvenience caused to the journal and its readers.\u201d He did not provide an explanation for the problems cited by the journal.<\/p>\n<p class=\"css-140ip4z e1me5xab0\">The study had enrolled 210 patients with advanced lung cancer at Hunan Cancer Hospital in Changsha, a city in south-central China. Patients were randomly assigned to receive infusions of an immunotherapy \u2014 Merck\u2019s blockbuster drug Keytruda or Tyvyt, which is not approved in the United States \u2014 either before or after 3 p.m.<\/p>\n<p class=\"css-140ip4z e1me5xab0\">The study reported that tumors did not progress for 11 months in patients who received the earlier infusions, compared with six months for those given the later infusions. Patients receiving the earlier infusions lived for 28 months, compared with 17 months for those infused later in the day.<\/p>\n<\/div>\n<aside class=\"css-ew4tgv\" aria-label=\"companion column\"\/><\/div>\n<div data-testid=\"companionColumn-3\">\n<div class=\"css-53u6y8\">\n<p class=\"css-140ip4z e1me5xab0\">Those \u201cwere numbers we usually associate with new blockbuster drugs, not scheduling decisions,\u201d <a class=\"css-yywogo\" href=\"https:\/\/connection.asco.org\/do\/groundhog-day-oncology-why-timing-and-dose-may-matter-more-than-we-admit\" title=\"\" rel=\"noopener noreferrer\" target=\"_blank\">wrote<\/a> Dr. Gilberto Lopes, an oncologist at the University of Miami. And rescheduling a patient \u201ccosts nothing,\u201d he noted.<\/p>\n<p class=\"css-140ip4z e1me5xab0\">Dr. Anil Makam, an epidemiologist and health services researcher at the University of California, San Francisco, said such a drastic benefit, if real, would have prompted infusion clinics to overhaul staffing and scheduling to shift appointments to earlier in the day.<\/p>\n<p class=\"css-140ip4z e1me5xab0\">\u201cIf we believed the effects, it would be malpractice not to,\u201d he said.<\/p>\n<p class=\"css-140ip4z e1me5xab0\">But within days after the study\u2019s publication in Nature Medicine, online sleuths and physicians <a class=\"css-yywogo\" href=\"https:\/\/aaox2.substack.com\/p\/retract-until-verified?r=771z0v\" title=\"\" rel=\"noopener noreferrer\" target=\"_blank\">like Dr. Makam<\/a> began raising concerns on social media and in blog posts. Less than three weeks after the study was published, the journal published an <a class=\"css-yywogo\" href=\"https:\/\/www.nature.com\/articles\/s41591-025-04181-w#change-history\" title=\"\" rel=\"noopener noreferrer\" target=\"_blank\">editor\u2019s note<\/a> saying it was investigating the issues.<\/p>\n<p class=\"css-140ip4z e1me5xab0\">In a statement on Thursday, Dr. Jo\u00e3o Monteiro, chief editor of Nature Medicine, which is published by Springer Nature, said, \u201cWe are grateful to the research community for bringing these concerns to our attention.\u201d<\/p>\n<p class=\"css-140ip4z e1me5xab0\">Some scientists have long been intrigued by the idea of harnessing the body\u2019s circadian rhythms to try to make drugs more effective or less toxic. For example, enzymes that the body uses to break down certain medicines are more abundant at certain times of day.<\/p>\n<\/div>\n<aside class=\"css-ew4tgv\" aria-label=\"companion column\"\/><\/div>\n<div data-testid=\"companionColumn-4\">\n<div class=\"css-53u6y8\">\n<p class=\"css-140ip4z e1me5xab0\">But critics of the Chinese study argued that immunotherapy works very differently from fast-acting drugs like Tylenol. The drug Keytruda lingers in the body and takes effect over several weeks. The study did not identify a biological reason for a difference in treatment timing that would produce such a significant benefit.<\/p>\n<p class=\"css-140ip4z e1me5xab0\">\u201cThere wasn\u2019t any sound scientific rationale behind it,\u201d said Dr. Roy Herbst, the incoming director of the Dartmouth Cancer Center in New Hampshire and Vermont.<\/p>\n<p class=\"css-140ip4z e1me5xab0\">In March, a team led by European researchers <a class=\"css-yywogo\" href=\"https:\/\/cslide.ctimeetingtech.com\/coasis_21526\/attendee\/confcal\/show\/session\/5\" title=\"\" rel=\"noopener noreferrer\" target=\"_blank\">reported<\/a> the findings of an analysis that looked at whether more than 3,000 cancer patients across eight studies had received immunotherapy in the morning or the afternoon. Their study, funded by the drugmaker Roche, which sells a number of cancer drugs, concluded that timing was \u201cunlikely to be a critical determinant\u201d of how well patients did.<\/p>\n<p class=\"css-140ip4z e1me5xab0\">Other studies looking back at outcomes have <a class=\"css-yywogo\" href=\"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/fullarticle\/2848611\" title=\"\" rel=\"noopener noreferrer\" target=\"_blank\">found an association<\/a> between the time of day that patients receive a cancer immunotherapy and how well they fare. But the why remains unclear.<\/p>\n<p class=\"css-140ip4z e1me5xab0\">Doctors said it was possible that more energetic, healthier patients might opt for morning slots. Poorer or rural patients who live far from an infusion center \u2014 and tend to fare worse \u2014 might ask for afternoon slots because they need to spend the morning traveling to their appointment.<\/p>\n<\/div>\n<aside class=\"css-ew4tgv\" aria-label=\"companion column\"\/><\/div>\n<p><script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-6606220950177433\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<!-- ItShrt World News -->\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-client=\"ca-pub-6606220950177433\"\r\n     data-ad-slot=\"1882483372\"\r\n     data-ad-format=\"auto\"\r\n     data-full-width-responsive=\"true\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script>\r\n<br \/>\n<br \/><a href=\"https:\/\/www.nytimes.com\/2026\/06\/25\/business\/china-cancer-treatment-research-retraction.html\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Early this year, a medical journal article caught the attention of cancer patients and doctors worldwide because of its extraordinary<\/p>\n","protected":false},"author":1,"featured_media":86180,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[38],"tags":[4997,415,9114,349,934,1642,6403,9115,268],"class_list":["post-86179","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science","tag-academic-and-scientific-journals","tag-cancer","tag-cancer-journal","tag-china","tag-clinical-trials","tag-immune-system","tag-immunotherapy","tag-nature-medicine-journal","tag-research"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Medical Journal Retracts Study Claiming Cancer Therapy Is More Effective When Given in the Morning - World 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