{"id":3731,"date":"2025-02-03T19:50:18","date_gmt":"2025-02-03T19:50:18","guid":{"rendered":"https:\/\/site.itshrt.com\/worldnews\/fda-approves-studies-of-pig-organ-transplants-for-kidney-patients\/"},"modified":"2025-02-03T19:50:18","modified_gmt":"2025-02-03T19:50:18","slug":"fda-approves-studies-of-pig-organ-transplants-for-kidney-patients","status":"publish","type":"post","link":"https:\/\/site.itshrt.com\/worldnews\/fda-approves-studies-of-pig-organ-transplants-for-kidney-patients\/","title":{"rendered":"FDA Approves Studies of Pig Organ Transplants for Kidney Patients"},"content":{"rendered":"<p> <script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-6606220950177433\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<!-- ItShrt World News -->\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-client=\"ca-pub-6606220950177433\"\r\n     data-ad-slot=\"1882483372\"\r\n     data-ad-format=\"auto\"\r\n     data-full-width-responsive=\"true\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script>\r\n<br \/>\n<\/p>\n<div data-testid=\"companionColumn-0\">\n<div class=\"css-53u6y8\">\n<p class=\"css-at9mc1 evys1bk0\">American regulators have given the green light to two biotechnology companies for clinical trials that will transplant organs from genetically modified pigs into people with kidney failure. If successful, these studies could lead to the broader use of cross-species transplantation, a dream of medical scientists for centuries.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">One of the companies, United Therapeutics Corporation, will begin its trial with six patients, but that number could eventually rise to 50. The other, eGenesis, said it would begin with three patients and grow the study from there.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">\u201cWe are entering a transformative era in organ transplantation,\u201d said Mike Curtis, the president and chief executive of eGenesis.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">Over the past three years, five patients have been known to receive organs from pigs engineered by these companies \u2014 two who received hearts and three who received kidneys. But these surgeries were not part of a formal clinical trial. Most of the patients were critically ill and their transplants were allowed because they had run out of other treatment options.<\/p>\n<\/div>\n<aside class=\"css-ew4tgv\" aria-label=\"companion column\"\/><\/div>\n<div data-testid=\"companionColumn-1\">\n<div class=\"css-53u6y8\">\n<p class=\"css-at9mc1 evys1bk0\">The longest survivor to date is Towana Looney, a 53-year-old woman from Alabama who received a pig\u2019s kidney at NYU Langone Health in New York City in November. The four other organ recipients, who were far sicker when they underwent the transplants, died shortly after the procedures.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">More than 550,000 Americans have kidney failure and require dialysis, and about 100,000 of them are on a waiting list to receive a kidney. But there is an acute shortage of donated organs, with fewer than 25,000 transplants done in 2023. Many people die while waiting.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">Even if genetically engineered pig organs are proved to be safe and effective, it\u2019s unclear what they would cost and whether they would be covered by insurance.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">The United Therapeutics study, which is expected to begin midyear, will start with six patients who have been on dialysis for at least six months but do not have other serious medical problems. There will be a three-month waiting period between each transplant so that doctors can learn from the outcomes.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">If the first six transplants are successful, the trial will expand to include up to 50 participants in what is called a phaseless trial \u2014 a type of study that combines the traditional Phase 1, Phase 2 and Phase 3 trials and can lead directly to approval.<\/p>\n<\/div>\n<aside class=\"css-ew4tgv\" aria-label=\"companion column\"\/><\/div>\n<div data-testid=\"companionColumn-2\">\n<div class=\"css-53u6y8\">\n<p class=\"css-at9mc1 evys1bk0\">The patients will be monitored for 24 weeks and must agree to regular follow-ups for the rest of their lives, allowing researchers to check not only on their health statuses but also for pathogens that could cross from pigs to humans.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">Critics have raised concerns about the potential for known or unknown pathogens in pigs to spill over into the human population during such transplants, though the risk is thought to be small. Both companies raise their pigs in pathogen-free facilities that adhere to strict biosecurity protocols and regularly screen the animals for pathogens.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">Medical ethicists have also raised questions about how patients can fully consent to such experiments when there are so many unknown risks.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">In a worst-case scenario, the recipient of an animal\u2019s organ \u201ccould become infected with an undetected pathogen from the porcine source,\u201d said Christopher Bobier, an associate professor specializing in bioethics and health policy at Central Michigan University College of Medicine.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">He also said that it was difficult to explain these risks to someone dealing with the grueling nature of kidney dialysis, which involves being hooked up to a dialysis machine for three to four hours a day, three times a week. \u201cSaying no would be incredibly difficult,\u201d Dr. Bobier said. \u201cFully grasping the lifelong implications of that decision would be even harder.\u201d<\/p>\n<\/div>\n<aside class=\"css-ew4tgv\" aria-label=\"companion column\"\/><\/div>\n<div data-testid=\"companionColumn-3\">\n<div class=\"css-53u6y8\">\n<p class=\"css-at9mc1 evys1bk0\">The kidneys produced by United Therapeutics come from pigs that have undergone 10 gene edits to improve the compatibility of their organs with human hosts: Six human genes were added and four porcine genes were inactivated \u2014 one that restricts the organs\u2019 growth and three that can cause human rejection.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">The eGenesis pigs have undergone 69 gene edits, includingchanges in 59 genes to inactivate viruses that are integrated into the pig\u2019s genome.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">The eGenesis trial will begin with three patients with kidney failure who are unlikely to receive a human organ within five years, Dr. Curtis said. There will be a six-month waiting period between the first and second patient, and then a lull of three months after that before the third, the company said.<\/p>\n<\/div>\n<aside class=\"css-ew4tgv\" aria-label=\"companion column\"\/><\/div>\n<p><script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-6606220950177433\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<!-- ItShrt World News -->\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-client=\"ca-pub-6606220950177433\"\r\n     data-ad-slot=\"1882483372\"\r\n     data-ad-format=\"auto\"\r\n     data-full-width-responsive=\"true\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script>\r\n<br \/>\n<br \/><a href=\"https:\/\/www.nytimes.com\/2025\/02\/03\/health\/pig-kidney-transplants-clinical-trials.html\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>American regulators have given the green light to two biotechnology companies for clinical trials that will transplant organs from genetically<\/p>\n","protected":false},"author":1,"featured_media":3732,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[36],"tags":[188],"class_list":["post-3731","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health-2","tag-your-feed-science"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>FDA Approves Studies of Pig Organ Transplants for Kidney Patients - World News<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/site.itshrt.com\/worldnews\/fda-approves-studies-of-pig-organ-transplants-for-kidney-patients\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta 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