{"id":18177,"date":"2025-04-08T20:11:59","date_gmt":"2025-04-08T20:11:59","guid":{"rendered":"https:\/\/site.itshrt.com\/worldnews\/the-dire-wolf-which-went-extinct-12500-years-ago-revived-by-biotech-company\/"},"modified":"2025-04-08T20:11:59","modified_gmt":"2025-04-08T20:11:59","slug":"the-dire-wolf-which-went-extinct-12500-years-ago-revived-by-biotech-company","status":"publish","type":"post","link":"https:\/\/site.itshrt.com\/worldnews\/the-dire-wolf-which-went-extinct-12500-years-ago-revived-by-biotech-company\/","title":{"rendered":"The dire wolf, which went extinct 12,500 years ago, revived by biotech company"},"content":{"rendered":"<p> <script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-6606220950177433\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<!-- ItShrt World News -->\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-client=\"ca-pub-6606220950177433\"\r\n     data-ad-slot=\"1882483372\"\r\n     data-ad-format=\"auto\"\r\n     data-full-width-responsive=\"true\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script>\r\n<br \/>\n<\/p>\n<div id=\"\">\n<p>For the first time ever, scientists say they have made a species de-extinct, bringing the dire wolf back into the world thousands of years after it died off.\u00a0<\/p>\n<p><a href=\"https:\/\/colossal.com\/direwolf\/science\/\" target=\"_blank\" rel=\"nofollow noopener\">Colossal Biosciences<\/a>, a company based in Dallas, says it successfully birthed three dire wolves \u2014 a species that once roamed North America but has been extinct for more than 12,500 years \u2014 using revolutionary science.<\/p>\n<p>Colossal CEO Ben Lamm said the team used DNA from a 13,000-year-old tooth and a 72,000-year-old skull to analyze the full genome of the species and create three healthy dire wolf puppies, according to a news release.<\/p>\n<figure class=\"embed embed--type-image is-image embed--float-none embed--size-medium\">\n<p>      <span class=\"img embed__content\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/assets2.cbsnewsstatic.com\/hub\/i\/r\/2025\/04\/08\/dbf5d432-2352-43cc-8ba5-8f8e6313bc6e\/thumbnail\/1240x832\/87dd7dae9181dec5bf0842f82b342694\/2411-dw-1month-6.jpg?v=7613930c2bdb7d1bf55be910a9b022f2#\" alt=\"Dire wolf puppies \" height=\"832\" width=\"1240\" loading=\"lazy\"\/><\/span><figcaption class=\"embed__caption-container\">\n<p>                  <span class=\"embed__caption\">Colossal Biosciences said it&#8217;s created three dire wolf puppies. Romulus and Remus, the two males, were born in October, while Khaleesi, the female, was born in January. \u00a0<\/span><\/p>\n<p>                  <span class=\"embed__credit\"><\/p>\n<p>                Colossal Biosciences<\/p>\n<p>                          <\/span><br \/>\n              <\/figcaption><\/figure>\n<p>The Colossal website explains that many dire wolf fossils were preserved in the La Brea tar pits, in the Los Angeles area, but the species&#8217; DNA was not preserved in the tar.\u00a0<\/p>\n<p>But using two dire wolf samples from an international study on the extinct species, Colossal was able to uncover more dire wolf DNA that ever previously found. Company scientists were eventually able to analyze the species&#8217; genome \u2014 or its entire DNA set.\u00a0<\/p>\n<p>Then they used CRISPR, a gene-editing technology, to genetically modify cells from a living gray wolf. Usually, cloning relies on tissue samples, but Colossal was able to use these modified cells to create embryos, then transferred them to a surrogate (a domestic dog, The Associated Press reported) to grow.\u00a0<\/p>\n<p>Three litters of dire wolf puppies yielded two males, named Romulus and Remus, and a female, named Khaleesi after the &#8220;Game of Thrones&#8221; character \u2014 a nod to the HBO fantasy drama that featured dire wolves.<\/p>\n<figure class=\"embed embed--type-image is-image embed--float-none embed--size-medium\">\n<p>      <span class=\"img embed__content\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/assets3.cbsnewsstatic.com\/hub\/i\/r\/2025\/04\/08\/66c0f30a-8630-45db-98b0-1f708b8312df\/thumbnail\/1240x891\/251f399ad3c9b7abd343367476e6322b\/screenshot-2025-04-08-at-11-16-31-am.png?v=7613930c2bdb7d1bf55be910a9b022f2#\" alt=\"dire wolf pups \" height=\"891\" width=\"1240\" loading=\"lazy\"\/><\/span><figcaption class=\"embed__caption-container\">\n<p>                  <span class=\"embed__caption\">For the first time ever, scientists have made a species de-extinct, bringing the dire wolf back into the ecosystem about 12,500 years after it died off.\u00a0<\/span><\/p>\n<p>                  <span class=\"embed__credit\"><\/p>\n<p>                Colossal Biosciences<\/p>\n<p>                          <\/span><br \/>\n              <\/figcaption><\/figure>\n<p>However, critics say the physical and genetic resemblance to an extinct species falls short of a full revival.<\/p>\n<p>&#8220;All you can do now is make something look superficially like something else,&#8221; Vincent Lynch, a biologist at the University at Buffalo who was not involved in the research, told The AP.<\/p>\n<p>&#8220;Whatever ecological function the dire wolf performed before it went extinct, it can&#8217;t perform those functions&#8221; in today&#8217;s environment, Lynch said.<\/p>\n<p>The company says the animals are being cared for on a 2,000-acre preserve, &#8220;certified by the American Humane Society and registered with USDA,&#8221; enclosed by a 10-foot-tall fence and perimeter security.\u00a0<\/p>\n<p>Colossal was also able to create two litters of cloned red wolves, which are the most critically endangered wolf in the world.<\/p>\n<p>The company says its de-extinction process could help support conservation efforts globally. &#8220;Preserving, expanding, and testing genetic diversity should be done well before important endangered animal species like the red wolf are lost,&#8221; said Harvard geneticist and co-founder of Colossal, Dr. George Church.\u00a0<\/p>\n<p>In 2021, Colossal announced plans to de-extinct the woolly mammoth \u2014 a concept Church had been developing for years. He <span class=\"link\"><a href=\"https:\/\/www.cbsnews.com\/news\/siberia-pleistocene-park-bringing-back-pieces-of-the-ice-age-to-combat-climate-change-60-minutes\/\" target=\"_blank\" data-invalid-url-rewritten-http=\"\">told &#8220;60 Minutes&#8221; in 2019<\/a><\/span>, &#8220;I would say that probably in five years we&#8217;ll know whether we can get this to work for mice, and maybe pigs and elephants. And then if we can get embryos to grow in the laboratory all the way to term, then it&#8217;s probably a decade.&#8221;<\/p>\n<p>Last month, the company said its scientists have simultaneously edited seven genes in mice embryos to create mice with long, thick, woolly hair \u2014 dubbing its creation\u00a0<span class=\"link\"><a href=\"https:\/\/www.cbsnews.com\/news\/mice-genetically-engineered-thick-hair-extinct-woolly-mammoth\/\" target=\"_blank\" data-invalid-url-rewritten-http=\"\">the &#8220;Colossal woolly mouse.&#8221;<\/a><\/span><\/p>\n<p>While the results and images of the the shaggy-haired mice were posted online, Colossal did not publish its research in a peer-reviewed journal and it has not been vetted by independent scientists.\u00a0<\/p>\n<p>The scientists edited mouse genes related to their hair and fat metabolism \u2014 two qualities woolly mammoths needed to survive in their Arctic habitat. After confirming the gene modification process works in mice, they planned on testing it with elephants, which are woolly mammoth&#8217;s closest living relatives. But, since Asian elephants are endangered, the company will face a number of additional hurdles. It is also doing work aimed at protecting the world&#8217;s\u00a0<a href=\"https:\/\/colossal.com\/elephant-conservation\/\" target=\"_blank\" rel=\"nofollow noopener\">elephant populations<\/a>.<\/p>\n<p>    <!-- data-recirc-source=\"queryly\" --><\/p>\n<aside class=\"component list recirculation component--type-recirculation \">\n<p><h3 class=\"component__title\">More from CBS News<\/h3>\n<\/p>\n<\/aside>\n<p>    <!-- tags --><\/p>\n<div class=\"content-author\">\n      <a href=\"https:\/\/www.cbsnews.com\/team\/caitlin-okane\/\" class=\"content-author__name\" data-invalid-url-rewritten-http=\"\">Caitlin O&#8217;Kane<\/a><\/p>\n<div class=\"content-author__bio\">\n<div class=\"content-author__full-information\">\n<p class=\"content-author__text\">Caitlin O&#8217;Kane is a New York City journalist who works on the CBS News social media team as a senior manager of content and production. She writes about a variety of topics and produces &#8220;The Uplift,&#8221; CBS News&#8217; streaming show that focuses on good news.<\/p>\n<\/p><\/div>\n<\/p><\/div>\n<\/p><\/div>\n<\/p><\/div>\n<p><script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-6606220950177433\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<!-- ItShrt World News -->\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-client=\"ca-pub-6606220950177433\"\r\n     data-ad-slot=\"1882483372\"\r\n     data-ad-format=\"auto\"\r\n     data-full-width-responsive=\"true\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script>\r\n<br \/>\n<br \/><a href=\"https:\/\/www.cbsnews.com\/news\/dire-wolf-extinct-dna-puppies-colossal-biosciences\/\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>For the first time ever, scientists say they have made a species de-extinct, bringing the dire wolf back into the<\/p>\n","protected":false},"author":1,"featured_media":18178,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[38],"tags":[1310],"class_list":["post-18177","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science","tag-dna"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>The dire wolf, which went extinct 12,500 years ago, revived by biotech company - World News<\/title>\n<meta name=\"description\" content=\"Colossal Biosciences said it used ancient DNA from the extinct species to create three dire wolf pups named Romulus, Remus and Khaleesi.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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