{"id":17953,"date":"2025-04-07T14:22:09","date_gmt":"2025-04-07T14:22:09","guid":{"rendered":"https:\/\/site.itshrt.com\/worldnews\/as-rfk-jr-champions-chronic-disease-prevention-key-research-is-cut\/"},"modified":"2025-04-07T14:22:09","modified_gmt":"2025-04-07T14:22:09","slug":"as-rfk-jr-champions-chronic-disease-prevention-key-research-is-cut","status":"publish","type":"post","link":"https:\/\/site.itshrt.com\/worldnews\/as-rfk-jr-champions-chronic-disease-prevention-key-research-is-cut\/","title":{"rendered":"As RFK Jr. Champions Chronic Disease Prevention, Key Research Is Cut"},"content":{"rendered":"<p> <script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-6606220950177433\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<!-- ItShrt World News -->\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-client=\"ca-pub-6606220950177433\"\r\n     data-ad-slot=\"1882483372\"\r\n     data-ad-format=\"auto\"\r\n     data-full-width-responsive=\"true\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script>\r\n<br \/>\n<\/p>\n<div data-testid=\"companionColumn-0\">\n<div class=\"css-53u6y8\">\n<p class=\"css-at9mc1 evys1bk0\">Robert F. Kennedy Jr. has spoken of an \u201cexistential threat\u201d that he said can destroy the nation.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">\u201cWe have the highest chronic disease burden of any country in the world,\u201d Mr. Kennedy said at a hearing in January before the Senate confirmed him as the secretary of Health and Human Services.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">And on Monday he is starting a tour in the Southwest to promote a program to combat chronic illness, emphasizing nutrition and lifestyle.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">But since Mr. Kennedy assumed his post, key grants and contracts that directly address these diseases, including obesity, diabetes and dementia, which experts agree are among the nation\u2019s leading health problems, are being eliminated.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">These programs range in scale and expense. Researchers warn that their demise could mean lost opportunities to address an aspect of public health that Mr. Kennedy has said is his priority.<\/p>\n<\/div>\n<aside class=\"css-ew4tgv\" aria-label=\"companion column\"\/><\/div>\n<div data-testid=\"companionColumn-1\">\n<div class=\"css-53u6y8\">\n<p class=\"css-at9mc1 evys1bk0\">\u201cThis is a huge mistake,\u201d said Dr. Ezekiel Emanuel, the co-director of the Healthcare Transformation Institute at the University of Pennsylvania\u2019s Perelman School of Medicine.<\/p>\n<h3 class=\"css-15h6bi9 e1gnsphs0\" id=\"link-59a28a33\"><span>Decades of Diabetes Research Discontinued<\/span><\/h3>\n<p class=\"css-at9mc1 evys1bk0\">Ever since its start in 1996, the Diabetes Prevention Program has helped doctors understand this deadly chronic disease. The condition is the nation\u2019s most expensive, affecting <a class=\"css-yywogo\" href=\"https:\/\/www.cdc.gov\/diabetes\/php\/data-research\/index.html#:~:text=Total:%2038.4%20million%20people%20have,older%20(48.8%25)%20have%20prediabetes\" title=\"\" rel=\"noopener noreferrer\" target=\"_blank\">38 million<\/a> Americans and incurring <a class=\"css-yywogo\" href=\"https:\/\/diabetesjournals.org\/care\/article\/47\/1\/26\/153797\/Economic-Costs-of-Diabetes-in-the-U-S-in-2022\" title=\"\" rel=\"noopener noreferrer\" target=\"_blank\">$306 billion<\/a> in one recent year in direct costs. With about <a class=\"css-yywogo\" href=\"https:\/\/diabetes.org\/about-diabetes\/statistics\/about-diabetes\" title=\"\" rel=\"noopener noreferrer\" target=\"_blank\">400,000 deaths<\/a> in 2021, it was the eighth leading cause of death.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">The program has been terminated, and the reason has little to do with its merits. Instead, it seems to be a matter of a lead researcher\u2019s working in the wrong place at the wrong time.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">The program began when doctors at 27 medical centers received funding from the National Institutes of Health for a study asking whether Type 2 diabetes could be prevented. The 3,234 participants had high risk of the disease.<\/p>\n<\/div>\n<aside class=\"css-ew4tgv\" aria-label=\"companion column\"\/><\/div>\n<div data-testid=\"companionColumn-2\">\n<div class=\"css-53u6y8\">\n<p class=\"css-at9mc1 evys1bk0\">The results were a huge victory. Those assigned to follow a healthy diet and exercise routine regularly reduced their chances of developing diabetes by 58 percent. Those who took metformin, a drug that lowers blood sugar, decreased their risk by 31 percent.<\/p>\n<\/div>\n<aside class=\"css-ew4tgv\" aria-label=\"companion column\"\/><\/div>\n<div data-testid=\"companionColumn-3\">\n<div class=\"css-53u6y8\">\n<p class=\"css-at9mc1 evys1bk0\">The program entered a new phase, led by Dr. David M. Nathan, a diabetes expert at Harvard Medical School. Researchers followed the participants to see how they fared without the constant attention and support of a clinical trial. The researchers also examined their genetics and metabolism and looked at measures of frailty and cognitive function.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">Several years ago, the investigators had an idea. Some studies suggested that people with diabetes had a higher risk of dementia. But scientists didn\u2019t know if it was vascular dementia or Alzheimer\u2019s or what the precise risk factors were. The diabetes program could renew its focus on investigating this with its 1,700 aging participants.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">The group added a new principal investigator, the dementia expert Dr. Jose A. Luchsinger. For administrative reasons, including the newfound focus on dementia, the program decided its money should flow through Dr. Luchsinger\u2019s home institution, Columbia University, rather than through Harvard or George Washington University, where a third principal investigator works.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">On March 7, the Trump administration cut <a class=\"css-yywogo\" href=\"https:\/\/www.nytimes.com\/2025\/03\/07\/nyregion\/trump-administration-columbia-grants-cancelled-antisemitism.html\" title=\"\">$400 million in grants and contracts to Columbia<\/a>, saying Jewish students were not protected from harassment during protests over the war in Gaza. The <a class=\"css-yywogo\" href=\"https:\/\/www.nytimes.com\/2025\/03\/18\/nyregion\/columbia-research-grants-trump.html\" title=\"\">diabetes grant was among those terminated<\/a>: $16 million a year that Columbia shared across 30 medical centers. The study ended abruptly.<\/p>\n<\/div>\n<aside class=\"css-ew4tgv\" aria-label=\"companion column\"\/><\/div>\n<div data-testid=\"companionColumn-4\">\n<div class=\"css-53u6y8\">\n<p class=\"css-at9mc1 evys1bk0\">Asked about the termination, Andrew G. Nixon, director of communications at Health and Human Services, provided a statement from the agency\u2019s acting general counsel saying that \u201canti-Semitism is clearly inconsistent with the fundamental values that should inform liberal education\u201d and that \u201cColumbia University\u2019s complacency is unacceptable.\u201d<\/p>\n<p class=\"css-at9mc1 evys1bk0\">At the time their grant ended, the researchers had started advanced cognitive testing for evidence of dementia in patients, followed by brain imaging to look for amyloid, the hallmark of Alzheimer\u2019s disease. They planned to complete the tests during the next two years.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">Then, Dr. Luchsinger said, the group was going to look at blood biomarkers of amyloid and other signs of dementia, including brain inflammation. For comparison, they planned to perform the same tests on participants\u2019 blood samples from 7 and 15 years ago.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">\u201cVery few studies have blood collected and stored going that far back,\u201d Dr. Luchsinger said.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">Now much of the work cannot begin, and the part that had started remains incomplete.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">Another troubling question the researchers hoped to answer was whether metformin increases, decreases or has no effect on the risk of dementia.<\/p>\n<\/div>\n<aside class=\"css-ew4tgv\" aria-label=\"companion column\"\/><\/div>\n<div data-testid=\"companionColumn-5\">\n<div class=\"css-53u6y8\">\n<p class=\"css-at9mc1 evys1bk0\">\u201cThis is the largest and longest study of metformin ever,\u201d Dr. Luchsinger said. Participants assigned to take the drug in the 1990s took it for more than 20 years.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">\u201cWe thought we had the potential to put to rest this question about metformin,\u201d Dr. Luchsinger said.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">The only ways to save the program, Dr. Nathan said, are for Mr. Kennedy to agree to restore the funding at Columbia or to transfer the grant to a principal investigator at another medical center.<\/p>\n<\/div>\n<aside class=\"css-ew4tgv\" aria-label=\"companion column\"\/><\/div>\n<div data-testid=\"companionColumn-6\">\n<div class=\"css-53u6y8\">\n<p class=\"css-at9mc1 evys1bk0\">The study investigators are appealing to the diabetes caucus in Congress, hoping it can help make their case to the Health and Human Services.<\/p>\n<\/div>\n<aside class=\"css-ew4tgv\" aria-label=\"companion column\"\/><\/div>\n<div data-testid=\"companionColumn-7\">\n<div class=\"css-53u6y8\">\n<p class=\"css-at9mc1 evys1bk0\">\u201cWe hope the congressmen and senators might prevail and say: \u2018This is crazy. This is chronic disease. This is what you wanted to study,\u2019\u201d Dr. Nathan said.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">So far, there has been no change.<\/p>\n<h3 class=\"css-15h6bi9 e1gnsphs0\" id=\"link-4e8b730f\"><span>Include Diversity. Actually, That\u2019s Too Much Diversity.<\/span><\/h3>\n<p class=\"css-at9mc1 evys1bk0\">Compared with the Diabetes Prevention Program, a program to train pediatricians to become scientists is tiny. But pediatric researchers say that <a class=\"css-yywogo\" href=\"https:\/\/amspdc-psdp.org\/\" title=\"\" rel=\"noopener noreferrer\" target=\"_blank\">the Pediatric Scientist Development Program<\/a> helps ensure that chronic childhood diseases are included in medical research.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">It began 40 years ago when chairs of pediatric departments called for the creation of the program, which has been continually funded ever since by the National Institute of Child Health and Human Development.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">Participants are clinicians who were trained in subspecialties like endocrinology and nephrology, practiced as clinicians and were inspired to go into research to help young patients with the diseases they had seen firsthand.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">The highly competitive program pays for seven to eight pediatricians to train at university medical centers for a year, pairing them with mentors and giving them time away from the clinic to research conditions including obesity, asthma and chronic kidney disease.<\/p>\n<\/div>\n<aside class=\"css-ew4tgv\" aria-label=\"companion column\"\/><\/div>\n<div data-testid=\"companionColumn-8\">\n<div class=\"css-53u6y8\">\n<p class=\"css-at9mc1 evys1bk0\">In retrospect, the program\u2019s fate was sealed in 2021 when its leaders applied for a renewal of their grant. It seemed pro forma. This was its eighth renewal.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">This time, though, an external committee of grant reviewers told the investigators their proposal\u2019s biggest weakness was a lack of diversity. The program needed to seek pediatricians who represented diverse ethnicities, economic backgrounds, states, types of research and pediatric specialties.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">The critique said, for example, that \u201cattention must be given to recruiting applicants from diverse backgrounds, including from groups that have been shown to be nationally underrepresented in the biomedical, behavioral, clinical and social sciences.\u201d<\/p>\n<p class=\"css-at9mc1 evys1bk0\">So the program\u2019s leaders sprinkled diversity liberally through a rewritten grant application.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">\u201cDiversity, in its broadest sense, was all over the grant,\u201d said Dr. Sallie Permar, professor and chairwoman of pediatrics at Weill Cornell Medical College and director of the program. \u201cIt was exactly what the reviewers appreciated when we resubmitted.\u201d<\/p>\n<p class=\"css-at9mc1 evys1bk0\">The grant was renewed in 2023. Now it is terminated. The reason? Diversity.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">The termination letter, from officials in the National Institute of Child Health and Human Development, said there was no point in trying to rewrite the grant request. The inclusion of diversity made the application so out of line that \u201cno modification of the project could align the project with agency priorities.\u201d<\/p>\n<\/div>\n<aside class=\"css-ew4tgv\" aria-label=\"companion column\"\/><\/div>\n<div data-testid=\"companionColumn-9\">\n<div class=\"css-53u6y8\">\n<p class=\"css-at9mc1 evys1bk0\">Mr. Nixon, the health department spokesman, did not reply to queries about the pediatric program\u2019s cancellation.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">Participants in the program are distraught.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">Dr. Sean Michael Cullen had been studying childhood obesity at Weill Cornell in New York. He has investigated why male mice fed a high-fat diet produced offspring that became fat, even when those offspring were fed a standard diet.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">He hoped his findings would help predict in humans which children were at risk of obesity so pediatricians could try to intervene.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">Now the funds are gone. He may seek private or philanthropic funding, but he doesn\u2019t have any clear prospects.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">Dr. Evan Rajadhyaksha is in a similar situation. He\u2019s a childhood kidney disease specialist at Indiana University. When he was a resident, he cared for a little girl who developed kidney disease because of a condition in which some urine washes up from the bladder into the kidneys.<\/p>\n<\/div>\n<aside class=\"css-ew4tgv\" aria-label=\"companion column\"\/><\/div>\n<div data-testid=\"companionColumn-10\">\n<div class=\"css-53u6y8\">\n<p class=\"css-at9mc1 evys1bk0\">Dr. Rajadhyaksha has a hypothesis that vitamin D supplementation could protect children with this condition.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">Now, that work has to stop. Without funding, he expects to leave research and return to clinical work.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">Dr. Permar said she hadn\u2019t given up. The program costs only $1.5 million each year, so she and her colleagues are looking for other support.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">\u201cWe are asking foundations,\u201d she said. \u201cWe are starting to ask industry \u2014 we haven\u2019t had industry funding before. We are asking department chairs and children\u2019s hospitals, are they willing to fund-raise?\u201d<\/p>\n<p class=\"css-at9mc1 evys1bk0\">\u201cWe are literally looking under every couch cushion,\u201d Dr. Permar said.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">\u201cBut,\u201d she said, federal support for the program \u201chas been the foundation and cannot be supplanted.\u201d<\/p>\n<\/div>\n<aside class=\"css-ew4tgv\" aria-label=\"companion column\"\/><\/div>\n<p><script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-6606220950177433\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<!-- ItShrt World News -->\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-client=\"ca-pub-6606220950177433\"\r\n     data-ad-slot=\"1882483372\"\r\n     data-ad-format=\"auto\"\r\n     data-full-width-responsive=\"true\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script>\r\n<br \/>\n<br \/><a href=\"https:\/\/www.nytimes.com\/2025\/04\/07\/health\/rfk-hhs-diabetes-obesity-disease.html\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Robert F. Kennedy Jr. has spoken of an \u201cexistential threat\u201d that he said can destroy the nation. \u201cWe have the<\/p>\n","protected":false},"author":1,"featured_media":17954,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[36],"tags":[1415,1100,2672,1411,929,271,243,337,4358,144,915,5667,982,268,916,111],"class_list":["post-17953","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health-2","tag-alzheimers-disease","tag-chronic-condition-health","tag-columbia-university","tag-dementia","tag-diabetes","tag-diet-and-nutrition","tag-diversity-initiatives","tag-federal-aid-us","tag-harvard-medical-school","tag-health-and-human-services-department","tag-kennedy","tag-national-institute-of-child-health-and-human-development","tag-national-institutes-of-health","tag-research","tag-robert-f-jr","tag-united-states-politics-and-government"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>As RFK Jr. Champions Chronic Disease Prevention, Key Research Is Cut - World News<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/site.itshrt.com\/worldnews\/as-rfk-jr-champions-chronic-disease-prevention-key-research-is-cut\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"As RFK Jr. Champions Chronic Disease Prevention, Key Research Is Cut - World News\" \/>\n<meta property=\"og:description\" content=\"Robert F. 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