{"id":16381,"date":"2025-03-30T19:01:58","date_gmt":"2025-03-30T19:01:58","guid":{"rendered":"https:\/\/site.itshrt.com\/worldnews\/eli-lilly-drug-reduces-mysterious-lpa-particle-involved-in-heart-attack-risk\/"},"modified":"2025-03-30T19:01:58","modified_gmt":"2025-03-30T19:01:58","slug":"eli-lilly-drug-reduces-mysterious-lpa-particle-involved-in-heart-attack-risk","status":"publish","type":"post","link":"https:\/\/site.itshrt.com\/worldnews\/eli-lilly-drug-reduces-mysterious-lpa-particle-involved-in-heart-attack-risk\/","title":{"rendered":"Eli Lilly Drug Reduces Mysterious Lp(a) Particle Involved in Heart Attack Risk"},"content":{"rendered":"<p> <script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-6606220950177433\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<!-- ItShrt World News -->\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-client=\"ca-pub-6606220950177433\"\r\n     data-ad-slot=\"1882483372\"\r\n     data-ad-format=\"auto\"\r\n     data-full-width-responsive=\"true\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script>\r\n<br \/>\n<\/p>\n<div data-testid=\"companionColumn-0\">\n<div class=\"css-53u6y8\">\n<p class=\"css-at9mc1 evys1bk0\">As many as one in five people \u2014 an estimated 64 million in the United States \u2014 have elevated levels of a tiny particle in their blood. It can greatly increase the risk of heart attacks and strokes.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">But few know about it, and almost no doctors test for it, because there was not much to be done. Diet does not help. Neither does exercise. There have been no drugs.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">But in the near future, that may change.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">On Sunday, cardiologists announced that an experimental drug made by Eli Lilly, lepodisiran, could lower levels of the particle, Lp(a), by 94 percent with a single injection. The effects lasted for six months and there were no significant side effects.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">But it is not yet confirmed that reducing Lp(a) levels also reduces the risk of heart attacks and strokes. That awaits large clinical trials that are now underway.<\/p>\n<\/div>\n<aside class=\"css-ew4tgv\" aria-label=\"companion column\"\/><\/div>\n<div data-testid=\"companionColumn-1\">\n<div class=\"css-53u6y8\">\n<p class=\"css-at9mc1 evys1bk0\">The Lilly research was presented Sunday at the annual meeting of the American College of Cardiology and simultaneously <a class=\"css-yywogo\" href=\"http:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa2415818\" title=\"\" rel=\"noopener noreferrer\" target=\"_blank\">published<\/a> in the New England Journal of Medicine. At least four other companies are also testing innovative drugs that block the body\u2019s production of Lp(a), a mix of lipids and a protein.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">Dr. David Maron, a preventive cardiologist at Stanford not involved in the Lilly research, said the evidence of profound and long-lasting reduction in lipoprotein levels with lepodisiran was \u201cthrilling.\u201d<\/p>\n<p class=\"css-at9mc1 evys1bk0\">Dr. Martha Gulati, a preventive cardiologist at Cedars-Sinai Medical Center also not involved in the trial, said the study was \u201creally elegant.\u201d<\/p>\n<p class=\"css-at9mc1 evys1bk0\">Eli Lilly is now conducting a large clinical trial asking if its drug can prevent heart attacks or strokes or cardiovascular deaths. It will conclude in 2029. Clinical trials of other drugs targeting Lp(a) will conclude sooner. The first will be a study of a Novartis drug, injected monthly, with results expected in 2026.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">Cardiologists caution, though, that there is no guarantee the drugs will protect people. They remember too well a lesson learned from assuming that altering a risk factor can alter risk. Cardiologists once were enthusiastic about drugs that raised levels of HDL, known as the \u201cgood cholesterol.\u201d People with naturally high HDL levels had lower rates of heart disease. Those HDL-raising drugs <a class=\"css-yywogo\" href=\"https:\/\/www.nytimes.com\/2012\/05\/17\/health\/research\/hdl-good-cholesterol-found-not-to-cut-heart-risk.html\" title=\"\">did not help<\/a>.<\/p>\n<\/div>\n<aside class=\"css-ew4tgv\" aria-label=\"companion column\"\/><\/div>\n<div data-testid=\"companionColumn-3\">\n<div class=\"css-53u6y8\">\n<p class=\"css-at9mc1 evys1bk0\">Lp(a)-lowering \u201cis a huge new frontier in cardiovascular medicine,\u201d said Dr. Daniel Rader, a preventive cardiologist at the University of Pennsylvania\u2019s Perelman School of Medicine. Dr. Rader is a member of the scientific advisory board for Novartis and wrote an editorial to accompany the new paper.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">Treatments targeting Lp(a) have been a long time coming.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">The lipoprotein was identified in 1974 as a <a class=\"css-yywogo\" href=\"https:\/\/www.acc.org\/Latest-in-Cardiology\/Articles\/2022\/05\/01\/01\/42\/Cover-Story-Emerging-From-the-Shadows-Lp-a\" title=\"\" rel=\"noopener noreferrer\" target=\"_blank\">risk factor for heart disease<\/a> that is controlled by genes rather than lifestyle or environment.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">People with Lp(a) levels that are slightly higher than normal have about a 25 percent increased risk of a heart attack or a stroke. And very high levels \u2014 as seen in 10 percent of the population \u2014 can double the risk.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">Cardiologists say that often in patients with no obvious reason for having a heart attack or a stroke \u2014 whose cholesterol levels and blood pressure are normal and who do not smoke \u2014 they learn that the patients have high levels of Lp(a). Usually it turns out they also have family histories of unexplained heart disease.<\/p>\n<\/div>\n<aside class=\"css-ew4tgv\" aria-label=\"companion column\"\/><\/div>\n<div data-testid=\"companionColumn-4\">\n<div class=\"css-53u6y8\">\n<p class=\"css-at9mc1 evys1bk0\">The same goes for people having heart attacks at a young age, said Dr. Steven Nissen, a preventive cardiologist at the Cleveland Clinic who is the academic leader for the Lilly drug trial and for clinical trials of three other new drugs.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">\u201cIf you go into the coronary care unit and see someone who is 40 years old with an acute myocardial infarction, you need to know the level of their Lp(a),\u201d he said, referring to a heart attack. All too often, he said, their levels are 250 nanomoles per liter or even higher. The upper limit of normal is 75.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">Dr. Maron said his clinic was full of people who had no idea why they developed heart disease, until they found out they had high levels of Lp(a).<\/p>\n<p class=\"css-at9mc1 evys1bk0\">One is Monte Wooden, a 71-year-old retired firefighter who lives in Redding, Calif. His LDL cholesterol levels were moderately elevated. His blood pressure was normal. He did not smoke. Yet he had his first heart attack in 2006 while taking a cholesterol-lowering statin.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">It seemed as if almost everyone in Mr. Wooden\u2019s family died from heart disease.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">His paternal grandmother had her first heart attack when she was in her 40s. She died from a heart attack at age 63. His father and his father\u2019s brother died from heart disease. Mr. Wooden\u2019s brother died from a heart attack.<\/p>\n<\/div>\n<aside class=\"css-ew4tgv\" aria-label=\"companion column\"\/><\/div>\n<div data-testid=\"companionColumn-5\">\n<div class=\"css-53u6y8\">\n<p class=\"css-at9mc1 evys1bk0\">When Dr. Maron tested Mr. Wooden\u2019s Lp(a) level, it was greater than 400.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">Dr. Maron and other preventive cardiologists, like Dr. Gulati, Dr. Nissen and Dr. Rader, say they routinely test all their patients\u2019 Lp(a) levels. Because Lp(a) levels are controlled by genes, they add, patients have to be tested only once.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">Dr. Nissen is blunt with his Lp(a) patients.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">\u201cWe say: You have a disorder with serious implications. I want to take every risk factor you have off the table,\u201d he said.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">Yet, Dr. Gulati said, one study found that just <a class=\"css-yywogo\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10547299\/\" title=\"\" rel=\"noopener noreferrer\" target=\"_blank\">0.3 percent<\/a> of the U.S. population has had an Lp(a) test \u2014 which is paid for by insurance \u2014 and just 3 percent of those with heart disease have been tested.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">She and other preventive cardiologists say all adults should have an Lp(a) test. If levels are high, doctors should aggressively treat every other risk factor.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">For Mr. Wooden, that meant taking a powerful cholesterol-lowering drug, Repatha, that got his LDL cholesterol level down to 30.<\/p>\n<\/div>\n<aside class=\"css-ew4tgv\" aria-label=\"companion column\"\/><\/div>\n<div data-testid=\"companionColumn-6\">\n<div class=\"css-53u6y8\">\n<p class=\"css-at9mc1 evys1bk0\">Mr. Wooden\u2019s case, though, didn\u2019t end there. Dr. Maron got him into a clinical trial testing one of the new drugs that lower Lp(a) levels.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">During the trial, Mr. Wooden had no symptoms of heart disease \u2014 no chest pain, no breathlessness. When the trial ended, his symptoms came back, leading to a quadruple bypass operation.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">\u201cIt\u2019s anecdotal,\u201d Dr. Maron said, \u201cbut it speaks to the likelihood that these drugs prevent heart attacks.\u201d<\/p>\n<\/div>\n<aside class=\"css-ew4tgv\" aria-label=\"companion column\"\/><\/div>\n<p><script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-6606220950177433\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<!-- ItShrt World News -->\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-client=\"ca-pub-6606220950177433\"\r\n     data-ad-slot=\"1882483372\"\r\n     data-ad-format=\"auto\"\r\n     data-full-width-responsive=\"true\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script>\r\n<br \/>\n<br \/><a href=\"https:\/\/www.nytimes.com\/2025\/03\/30\/health\/heart-attack-lpa-protein.html\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>As many as one in five people \u2014 an estimated 64 million in the United States \u2014 have elevated levels<\/p>\n","protected":false},"author":1,"featured_media":16382,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[38],"tags":[934,139,5220,2163,5219,5221,268,5148],"class_list":["post-16381","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science","tag-clinical-trials","tag-drugs-pharmaceuticals","tag-eli-lilly-and-company","tag-heart","tag-lipoproteins","tag-new-england-journal-of-medicine","tag-research","tag-stroke"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Eli Lilly Drug Reduces Mysterious Lp(a) Particle Involved in Heart Attack Risk - World News<\/title>\n<meta name=\"robots\" content=\"index, follow, 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