{"id":14547,"date":"2025-03-21T18:16:49","date_gmt":"2025-03-21T18:16:49","guid":{"rendered":"https:\/\/site.itshrt.com\/worldnews\/kilmer-mccully-pathologist-scorned-for-new-theory-of-heart-disease-dies-at-91\/"},"modified":"2025-03-21T18:16:49","modified_gmt":"2025-03-21T18:16:49","slug":"kilmer-mccully-pathologist-scorned-for-new-theory-of-heart-disease-dies-at-91","status":"publish","type":"post","link":"https:\/\/site.itshrt.com\/worldnews\/kilmer-mccully-pathologist-scorned-for-new-theory-of-heart-disease-dies-at-91\/","title":{"rendered":"Kilmer McCully, Pathologist Scorned for New Theory of Heart Disease, Dies at 91"},"content":{"rendered":"<p> <script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-6606220950177433\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<!-- ItShrt World News -->\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-client=\"ca-pub-6606220950177433\"\r\n     data-ad-slot=\"1882483372\"\r\n     data-ad-format=\"auto\"\r\n     data-full-width-responsive=\"true\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script>\r\n<br \/>\n<\/p>\n<div data-testid=\"companionColumn-0\">\n<div class=\"css-53u6y8\">\n<p class=\"css-at9mc1 evys1bk0\">Kilmer S. McCully, a pathologist at Harvard Medical School in the 1960s and \u201970s whose colleagues banished him to the basement for insisting \u2014 correctly, it turned out \u2014 that homocysteine, an amino acid, was being overlooked as a possible risk factor for heart disease, died on Feb. 21 at his home in Winchester, Mass. He was 91.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">His daughter, Martha McCully, said the cause was metastatic prostate cancer. His death was not widely reported at the time.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">Still a debated idea today, Dr. McCully\u2019s theory \u2014 that inadequate intake of certain B vitamins causes high levels of homocysteine in the blood, hardening the arteries with plaque \u2014 challenged the cholesterol-focused paradigm backed by the pharmaceutical industry.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">Dr. McCully didn\u2019t think cholesterol should be ignored, but he thought it was malpractice to disregard the significance of homocysteine. His bosses at Harvard disagreed. First, they moved his lab below ground; then they told him to leave. He struggled to find work for years.<\/p>\n<\/div>\n<aside class=\"css-ew4tgv\" aria-label=\"companion column\"\/><\/div>\n<div data-testid=\"companionColumn-1\">\n<div class=\"css-53u6y8\">\n<p class=\"css-at9mc1 evys1bk0\">\u201cIt was very traumatic,\u201d he <a class=\"css-yywogo\" href=\"https:\/\/www.nytimes.com\/1995\/07\/04\/science\/new-clue-to-heart-disease-a-vitamin-lack.html\" title=\"\">told<\/a> the New York Times medical reporter <a class=\"css-yywogo\" href=\"https:\/\/www.nytimes.com\/by\/gina-kolata\" title=\"\">Gina Kolata<\/a> in 1995. \u201cPeople don\u2019t believe you. They think you\u2019re crazy.\u201d<\/p>\n<p class=\"css-at9mc1 evys1bk0\">Dr. McCully, fashioning himself as a microbe hunter akin to Louis Pasteur, stumbled on homocysteine in the late 1960s at a medical conference in Boston. There he learned about <a class=\"css-yywogo\" href=\"https:\/\/medlineplus.gov\/genetics\/condition\/homocystinuria\/\" title=\"\" rel=\"noopener noreferrer\" target=\"_blank\">homocystinuria<\/a>, a genetic disease in which high amounts of homocysteine are found in the urine of some developmentally disabled children.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">Presenting the case of homocystinuria in a 9-year-old girl, doctors mentioned that her uncle had died from a stroke in the 1930s, when he was 8 and had the same disease. \u201cHow could an eight-year-old have died the way old people do?\u201d Dr. McCully wrote, with his daughter, in \u201cThe Heart Revolution\u201d (1999).<\/p>\n<div data-testid=\"imageblock-wrapper\">\n<figure class=\"img-sz-small css-1189og3 e1g7ppur0\" aria-label=\"media\" role=\"group\"><figcaption data-testid=\"photoviewer-children-caption\" class=\"css-13ytnnu ewdxa0s0\"><span class=\"css-jevhma e13ogyst0\">\u201cHow could an eight-year-old have died the way old people do?\u201d Dr. McCully wrote in \u201cThe Heart Revolution,\u201d recalling the case that led to his controversial research.<\/span><span class=\"css-14fe1uy e1z0qqy90\"><span class=\"css-1ly73wi e1tej78p0\">Credit&#8230;<\/span><span><span aria-hidden=\"false\">HarperCollins<\/span><\/span><\/span><\/figcaption><\/figure>\n<\/div>\n<p class=\"css-at9mc1 evys1bk0\">When Dr. McCully tracked down the autopsy report and tissue samples, he was astounded: The boy had hardened arteries, but there was no cholesterol or fat in the plaque buildup. A few months later, he learned about a baby boy with homocystinuria who had recently died. He also had hardened arteries.<\/p>\n<\/div>\n<aside class=\"css-ew4tgv\" aria-label=\"companion column\"\/><\/div>\n<div data-testid=\"companionColumn-2\">\n<div class=\"css-53u6y8\">\n<p class=\"css-at9mc1 evys1bk0\">\u201cI barely slept for two weeks,\u201d he wrote.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">In 1969, Dr. McCully published a paper about the cases in The American Journal of Pathology. The next year, in the same journal, he described what happened after he injected rabbits with high doses of homocysteine. \u201cThe aortas of all 13 of the animals injected with homocysteine were moderately thickened,\u201d he wrote, \u201ccompared to the controls.\u201d<\/p>\n<p class=\"css-at9mc1 evys1bk0\">Dr. McCully followed up with other studies. He suggested that people with low intake of folic acid and vitamins B6 and B12 should consume five servings of fruits and vegetables a day. He also recommended the development of blood tests for homocysteine.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">The medical profession responded with \u201cstony silence,\u201d Dr. McCully <a class=\"css-yywogo\" href=\"https:\/\/www.nytimes.com\/1995\/07\/04\/science\/new-clue-to-heart-disease-a-vitamin-lack.html\" title=\"\">told<\/a> The Times. In 1979, he said, the chairman of his department at Harvard told him, \u201cWe feel you haven\u2019t proved your theory.\u201d He decided to leave, and he was unemployed until 1981, when a Veterans Affairs hospital in Providence, R.I., hired him as a pathologist.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">\u201cI felt for him, and I admired him,\u201d J. David Spence, a professor emeritus at the University of Western Ontario who studies homocysteine, said in an interview. \u201cHe was neglected more than he ought to have been. It was sad.\u201d<\/p>\n<p class=\"css-at9mc1 evys1bk0\">That began to change in the early 1990s, when large-scale, long-term studies of the risks for heart disease revealed that Dr. McCully had, in fact, been heading down the right path when Harvard relegated him to the basement.<\/p>\n<\/div>\n<aside class=\"css-ew4tgv\" aria-label=\"companion column\"\/><\/div>\n<div data-testid=\"companionColumn-3\">\n<div class=\"css-53u6y8\">\n<p class=\"css-at9mc1 evys1bk0\">Data from the <a class=\"css-yywogo\" href=\"https:\/\/www.framinghamheartstudy.org\/\" title=\"\" rel=\"noopener noreferrer\" target=\"_blank\">Framingham Heart Study<\/a>, initiated in 1948 and still being conducted, showed higher rates of hardened arteries connected to the brain among participants with elevated homocysteine levels. A study by the Harvard School of Public Health and Brigham and Women\u2019s Hospital in Boston found that men with high homocysteine had a threefold greater risk of suffering a heart attack than men with lower levels.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">\u201cAt the end of the day, he was right in the sense that homocysteine is a marker for higher risk for cardiovascular disease,\u201d <a class=\"css-yywogo\" href=\"https:\/\/hsph.harvard.edu\/profile\/meir-stampfer\/\" title=\"\" rel=\"noopener noreferrer\" target=\"_blank\">Meir Stampfer,<\/a> a Harvard epidemiologist who helped lead the study, said in an interview. \u201cHe gets the credit for developing this theory and helping to provide the evidence for it.\u201d<\/p>\n<\/div>\n<aside class=\"css-ew4tgv\" aria-label=\"companion column\"\/><\/div>\n<div data-testid=\"companionColumn-4\">\n<div class=\"css-53u6y8\">\n<p class=\"css-at9mc1 evys1bk0\">Kilmer Serjus McCully was born on Dec. 23, 1933, in Daykin, Neb., and grew up in Alexandria, Va., near Washington. His father, Harold McCully, was a specialist in counseling psychology for the U.S. Department of Education. His mother, Lulu (Litwinenco) McCully, was an artist and a piano teacher.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">As a teenager, Kilmer was enthralled by \u201cMicrobe Hunters,\u201d Paul de Kruif\u2019s 1926 book about Pasteur, Walter Reed, Robert Koch and others who investigated infectious diseases. He knew almost immediately that he wanted to become a scientist.<\/p>\n<\/div>\n<aside class=\"css-ew4tgv\" aria-label=\"companion column\"\/><\/div>\n<div data-testid=\"companionColumn-5\">\n<div class=\"css-53u6y8\">\n<p class=\"css-at9mc1 evys1bk0\">He studied biochemistry, psychology and chemistry at Harvard, where he took classes with B.F. Skinner, and graduated in 1955. Known as Kim to his friends, he went on to earn his medical degree there in 1959. For part-time work, he babysat for the historian Arthur M. Schlesinger Jr. and served cocktails at Mr. Schlesinger\u2019s many parties.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">Following an internship and postdoctoral fellowship at Massachusetts General Hospital, Dr. McCully joined Harvard Medical School\u2019s pathology department in 1965.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">He married Annina Jacobs in 1955. She died in 2023.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">In addition to their daughter, Martha, he is survived by their son, Michael; two grandchildren; two great-grandchildren; and a sister, Marilyn Raeburn.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">After the studies in the 1990s supported his theory, Dr. McCully became something of a media star.<\/p>\n<\/div>\n<aside class=\"css-ew4tgv\" aria-label=\"companion column\"\/><\/div>\n<div data-testid=\"companionColumn-6\">\n<div class=\"css-53u6y8\">\n<p class=\"css-at9mc1 evys1bk0\">The New York Times Magazine featured him in a 1997 article headlined <a class=\"css-yywogo\" href=\"https:\/\/www.nytimes.com\/1997\/08\/10\/magazine\/the-fall-and-rise-of-kilmer-mccully.html\" title=\"\">\u201cThe Fall and Rise of Kilmer McCully.\u201d<\/a> On the NPR program \u201cFresh Air\u201d in 1999, he <a class=\"css-yywogo\" href=\"https:\/\/freshairarchive.org\/guests\/kilmer-s-mccully\" title=\"\" rel=\"noopener noreferrer\" target=\"_blank\">told<\/a> Terry Gross, the host, \u201cIt\u2019s extremely satisfying to me, because when I was a young person, this is what I wanted to do with my life.\u201d<\/p>\n<\/div>\n<aside class=\"css-ew4tgv\" aria-label=\"companion column\"\/><\/div>\n<div data-testid=\"companionColumn-7\">\n<div class=\"css-53u6y8\">\n<p class=\"css-at9mc1 evys1bk0\">But homocysteine remains a controversial subject in medicine.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">Major medical organizations have not recommended testing for it, citing mixed results from studies examining whether lowering homocysteine leads to a reduction in cardiovascular events. (There is stronger evidence that it can help prevent strokes.)<\/p>\n<p class=\"css-at9mc1 evys1bk0\">\u201cIt\u2019s a strange business to me that people still don\u2019t pay enough attention to this,\u201d Dr. Spence said. \u201cMaybe doctors didn\u2019t like their biochemistry lessons.\u201d<\/p>\n<p class=\"css-at9mc1 evys1bk0\">As for Harvard, Dr. McCully\u2019s family said he was never bitter about his treatment there. At a medical school reunion in 1999, his classmates presented him with a silver platter.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">It was inscribed, \u201cTo Kim McCully, who saw the truth before the rest of us, indeed before the rest of medicine, and who would not be turned aside.\u201d<\/p>\n<\/div>\n<aside class=\"css-ew4tgv\" aria-label=\"companion column\"\/><\/div>\n<p><script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-6606220950177433\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<!-- ItShrt World News -->\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-client=\"ca-pub-6606220950177433\"\r\n     data-ad-slot=\"1882483372\"\r\n     data-ad-format=\"auto\"\r\n     data-full-width-responsive=\"true\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script>\r\n<br \/>\n<br \/><a href=\"https:\/\/www.nytimes.com\/2025\/03\/21\/science\/kilmer-mccully-dead.html\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Kilmer S. McCully, a pathologist at Harvard Medical School in the 1960s and \u201970s whose colleagues banished him to the<\/p>\n","protected":false},"author":1,"featured_media":14548,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[36],"tags":[4626,441,844,4358,2163,4625,4624,551,3946],"class_list":["post-14547","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health-2","tag-cholesterol","tag-deaths-obituaries","tag-doctors","tag-harvard-medical-school","tag-heart","tag-kilmer-s","tag-mccully","tag-medicine-and-health","tag-vitamins"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Kilmer McCully, Pathologist Scorned for New Theory of Heart Disease, Dies at 91 - World News<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/site.itshrt.com\/worldnews\/kilmer-mccully-pathologist-scorned-for-new-theory-of-heart-disease-dies-at-91\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Kilmer McCully, Pathologist Scorned for New Theory of Heart Disease, Dies at 91 - World News\" \/>\n<meta property=\"og:description\" content=\"Kilmer S. 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