{"id":10677,"date":"2025-03-05T19:48:19","date_gmt":"2025-03-05T19:48:19","guid":{"rendered":"https:\/\/site.itshrt.com\/worldnews\/women-with-postpartum-depression-experienced-brain-changes-during-pregnancy-study-finds\/"},"modified":"2025-03-05T19:48:19","modified_gmt":"2025-03-05T19:48:19","slug":"women-with-postpartum-depression-experienced-brain-changes-during-pregnancy-study-finds","status":"publish","type":"post","link":"https:\/\/site.itshrt.com\/worldnews\/women-with-postpartum-depression-experienced-brain-changes-during-pregnancy-study-finds\/","title":{"rendered":"Women with Postpartum Depression Experienced Brain Changes During Pregnancy, Study Finds"},"content":{"rendered":"<p> <script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-6606220950177433\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<!-- ItShrt World News -->\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-client=\"ca-pub-6606220950177433\"\r\n     data-ad-slot=\"1882483372\"\r\n     data-ad-format=\"auto\"\r\n     data-full-width-responsive=\"true\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script>\r\n<br \/>\n<\/p>\n<div data-testid=\"companionColumn-0\">\n<div class=\"css-53u6y8\">\n<p class=\"css-at9mc1 evys1bk0\">Postpartum depression affects about one in every seven women who give birth, but little is known about what happens in the brains of pregnant women who experience it. A <a class=\"css-yywogo\" href=\"http:\/\/www.science.org\/doi\/10.1126\/sciadv.adt5619\" title=\"\" rel=\"noopener noreferrer\" target=\"_blank\">new study<\/a> begins to shed some light.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">Researchers scanned the brains of dozens of women in the weeks before and after childbirth and found that two brain areas involved in the processing and control of emotions increased in size in women who developed symptoms of postpartum depression.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">The results, published Wednesday in the journal Science Advances, constitute some of the first evidence that postpartum depression is associated with changes in the brain during pregnancy.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">Researchers found that women with symptoms of depression in the first month after giving birth also had increases in the volume of their amygdala, a brain area that plays a key role in emotional processing. Women who rated their childbirth experience as difficult or stressful \u2014 a perception that is often associated with postpartum depression \u2014 also showed increases in the volume of the hippocampus, a brain area that helps regulate emotions.<\/p>\n<\/div>\n<aside class=\"css-ew4tgv\" aria-label=\"companion column\"\/><\/div>\n<div data-testid=\"companionColumn-1\">\n<div class=\"css-53u6y8\">\n<p class=\"css-at9mc1 evys1bk0\">\u201cThis is really the first step in trying to understand how does the brain change in people who have a normal course of pregnancy and then those who experience perinatal depression, and what can we do about it,\u201d said Dr. Sheila Shanmugan, an assistant professor of psychiatry, obstetrics-gynecology and radiology at the University of Pennsylvania who was not involved in the study.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">\u201cThe big takeaways are about how there are these really profound brain changes during pregnancy and how now we\u2019re seeing it in depression circuitry specifically,\u201d she said.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">The study was conducted in Madrid by a team that has led efforts to document the effects of pregnancy on the brain. It is part of a <a class=\"css-yywogo\" href=\"https:\/\/www.nytimes.com\/2024\/09\/16\/health\/pregnancy-brain-changes.html\" title=\"\">growing body of research<\/a> that has found that certain brain networks, especially those involved in social and emotional processing, <a class=\"css-yywogo\" href=\"https:\/\/www.nytimes.com\/2016\/12\/19\/health\/pregnancy-brain-change.html\" title=\"\">shrink during pregnancy<\/a>, possibly undergoing a fine-tuning process in preparation for parenting. <a class=\"css-yywogo\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36414622\/\" title=\"\" rel=\"noopener noreferrer\" target=\"_blank\">Such changes<\/a> correspond with surges in pregnancy hormones, especially estrogen, and some last at least two years after childbirth, <a class=\"css-yywogo\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36414622\/\" title=\"\" rel=\"noopener noreferrer\" target=\"_blank\">researchers have found<\/a>.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">The new study appears to be the first to scan and compare brain areas during pregnancy and after childbirth and link the changes to postpartum depression, said Elseline Hoekzema, a neuroscientist who heads the Pregnancy and the Brain Lab at Amsterdam University Medical Center and was not involved in the study.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">The study authors and other researchers said it was not clear whether the increased volume in the amygdala and hippocampus drove depressive symptoms and perceptions of stress during childbirth or whether the brain changes were occurring in response to the symptoms and stressors. It was also unclear from the brain scans why some women seemed to be more vulnerable to these symptoms than others.<\/p>\n<\/div>\n<aside class=\"css-ew4tgv\" aria-label=\"companion column\"\/><\/div>\n<div data-testid=\"companionColumn-2\">\n<div class=\"css-53u6y8\">\n<p class=\"css-at9mc1 evys1bk0\">\u201cIt might be that those persons whose amygdala is more susceptible to change are also at higher risk of suffering postpartum depression,\u201d said the study\u2019s senior author, Susana Carmona, a neuroscientist who leads the Neuromaternal Laboratory at the Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n in Madrid. \u201cIt can also be the other way around,\u201d she said, \u201cthat somehow these depression symptoms produce an increase in the amygdala volume.\u201d<\/p>\n<p class=\"css-at9mc1 evys1bk0\">The researchers studied 88 pregnant women who had not previously given birth and who did not have previous histories of depression or other neuropsychiatric conditions. For a control group, they also looked at 30 women who were not pregnant. The pregnant women underwent brain scans during their third trimester and about a month after they gave birth.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">The women completed standard questionnaires to assess whether they had symptoms of postpartum depression. After childbirth, 15 women showed moderate symptoms of depression and another 13 showed symptoms of depression serious enough to warrant seeking medical help, Dr. Carmona said.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">The women also completed questionnaires about whether they perceived their childbirth experience as difficult. Previous studies have shown that \u201ca negative birth experience is associated with increases in depression scores,\u201d Dr. Carmona said. She said difficult childbirth experiences were not necessarily medically challenging deliveries, but could be uncomplicated deliveries that the women perceived as stressful because of factors like rude hospital staff.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">Laura Pritschet, a postdoctoral scholar in psychiatry at the University of Pennsylvania who was not involved in the study, called the results \u201creally fascinating,\u201d adding that they point the way to further research \u201ctrying to figure out which areas of the brain are changing the most in relation to a variety of outcomes after you give birth, such as mood, anxiety, depression.\u201d<\/p>\n<\/div>\n<aside class=\"css-ew4tgv\" aria-label=\"companion column\"\/><\/div>\n<div data-testid=\"companionColumn-3\">\n<div class=\"css-53u6y8\">\n<p class=\"css-at9mc1 evys1bk0\">Dr. Pritschet, who <a class=\"css-yywogo\" href=\"https:\/\/www.science.org\/doi\/10.1126\/sciadv.adt8104\" title=\"\" rel=\"noopener noreferrer\" target=\"_blank\">wrote an article<\/a> with Dr. Shanmugan in the same issue of the journal that advocates for research to determine individualized brain signatures of perinatal depression, said the findings of the new study help identify a road map for eventually improving the prediction, diagnosis and treatment of postpartum depression.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">\u201cIf we routinely show certain brain areas are implicated, what do we do? How can we intervene early?\u201d she said. \u201cWhat is the normal amount of change? Why might that area be vulnerable? Lots of interesting questions to ask next.\u201d<\/p>\n<\/div>\n<aside class=\"css-ew4tgv\" aria-label=\"companion column\"\/><\/div>\n<p><script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-6606220950177433\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<!-- ItShrt World News -->\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-client=\"ca-pub-6606220950177433\"\r\n     data-ad-slot=\"1882483372\"\r\n     data-ad-format=\"auto\"\r\n     data-full-width-responsive=\"true\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script>\r\n<br \/>\n<br \/><a href=\"https:\/\/www.nytimes.com\/2025\/03\/05\/health\/postpartum-depression-brain.html\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Postpartum depression affects about one in every seven women who give birth, but little is known about what happens in<\/p>\n","protected":false},"author":1,"featured_media":10678,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[38],"tags":[1068,2807,3637,3638,2766,1623,268,1864,550,145,188],"class_list":["post-10677","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science","tag-brain","tag-depression-mental","tag-emotions","tag-madrid-spain","tag-pregnancy-and-childbirth","tag-psychiatry-and-psychiatrists","tag-research","tag-science-advances-journal","tag-women-and-girls","tag-your-feed-healthcare","tag-your-feed-science"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Women with Postpartum Depression Experienced Brain Changes During Pregnancy, Study Finds - World News<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" 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